Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR-Mutant Lung Cancer.

Adam J SchoenfeldJoseph M ChanDaisuke KubotaHiroki SatoHira RizviYahya DaneshbodJason C ChangPaul K PaikMichael D OffinMaria E ArcilaMonika A DavareUjwal ShindeDana Pe'erNatasha RekhtmanMark G KrisRomel SomwarGregory J RielyMarc LadanyiHelena A Yu

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Histologic transformation and other off-target molecular alterations are frequent early emerging resistance mechanisms to osimertinib and are associated with poor clinical outcomes.See related commentary by Piotrowska and Hata, p. 2441.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
advanced non small cell lung cancer
tyrosine kinase
high grade
low grade
gene expression
drug induced