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Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR-Mutant Lung Cancer.

Adam J SchoenfeldJoseph M ChanDaisuke KubotaHiroki SatoHira RizviYahya DaneshbodJason C ChangPaul K PaikMichael D OffinMaria E ArcilaMonika A DavareUjwal ShindeDana Pe'erNatasha RekhtmanMark G KrisRomel SomwarGregory J RielyMarc LadanyiHelena A Yu
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Histologic transformation and other off-target molecular alterations are frequent early emerging resistance mechanisms to osimertinib and are associated with poor clinical outcomes.See related commentary by Piotrowska and Hata, p. 2441.
Keyphrases
  • small cell lung cancer
  • epidermal growth factor receptor
  • advanced non small cell lung cancer
  • tyrosine kinase
  • high grade
  • low grade
  • gene expression
  • drug induced