The Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms (rs3063368, rs755622) Predict Acute Kidney Injury and Death after Cardiac Surgery.
Luisa AverdunkJuergen BernhagenKarl FehnleHarald SurowyHermann-Josef LüdeckeSören MuchaPatrick MeybohmDagmar WieczorekLin LengGernot MarxDavid E LeafAlexander ZarbockKai Zacharowskinull On Behalf Of The RIPHeart Study CollaboratorsRichard BucalaChristian StoppePublished in: Journal of clinical medicine (2020)
The CATT7 allele associates with a higher risk of AKI and death after cardiac surgery, which might be related to chronically elevated serum MIF. Polymorphisms in the MIF gene may constitute a predisposition for postoperative complications and the assessment may improve risk stratification and therapeutic guidance.