Baseline Large-Scale Network Dynamics Associated with Disease Progression in Huntington's Disease.
Ignacio Aracil-BolañosJesús Pérez-PérezSaul-Indra Martinez-HortaAndrea Horta-BarbaArnau Puig-DaviJúlia García-CornetGonzalo Olmedo-SauraAntonia CampolongoJavier PagonabarragaJaime KulisevskyPublished in: Movement disorders : official journal of the Movement Disorder Society (2023)
Structural disruptions in HD were evident both in posterior parietal/occipital and frontal motor regions, with reciprocal increases in functional connectivity. However, although higher visuospatial network connectivity was tied to a smaller cUHDRS decline, increased motor and frontal default-mode connections were linked to a larger cUHDRS decreases. Therefore, divergent functional compensation mechanisms might be at play in the clinical evolution of HD.