Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing.
Shuxuan ZhengLidewij L W RümkeBruno Tello RubioMalbert R C RogersGeerte L van SluisJürgen H E KuballAnnelies Riezebos-BrilmanRobert Jan LebbinkFrans M Verduyn LunelPublished in: Open forum infectious diseases (2024)
We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, affecting the clinical response to aciclovir and foscarnet.
Keyphrases
- drug resistant
- multidrug resistant
- herpes simplex virus
- circulating tumor
- acinetobacter baumannii
- copy number
- hematopoietic stem cell
- gram negative
- case report
- klebsiella pneumoniae
- escherichia coli
- sars cov
- cell free
- genome wide
- gene expression
- circulating tumor cells
- single molecule
- intensive care unit
- dna methylation
- transcription factor
- cystic fibrosis
- combination therapy