Superior Effect of the Combination of Carbon-Ion Beam Irradiation and 5-Fluorouracil on Colorectal Cancer Stem Cells in vitro and in vivo.

Woong Sub KoomSei SaiMasao SuzukiAkira FujimoriShigeru YamadaHirohiko Tsujii

Published in: OncoTargets and therapy (2020)

In conclusion, carbon-ion beam treatment combined with 5-FU has the potential to kill CRC cells including CSCs by inducing increased apoptosis and autophagy.

Keyphrases

cell cycle arrest
endoplasmic reticulum stress
induced apoptosis
cell death
stem cells
oxidative stress
pi k akt
monte carlo
electron microscopy
radiation induced
cell proliferation
smoking cessation