Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Qingyang ZhangJuan ZhangJin YeXiaohui LiHongda LiuXiaolin MaChao WangKeqiang HeWei ZhangJi YuanYingjun ZhaoHuaxi XuQiang LiuPublished in: Molecular neurodegeneration (2021)
Our findings define a molecular mechanism by which hnRNP L-DL regulates alternative RNA splicing, and establish a direct role for L-DL in AD-related synaptic dysfunction and memory decline.