Constipation in Tg2576 mice model for Alzheimer's disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response.

Ji Eun KimJin Ju ParkMi Rim LeeJun Young ChoiBo Ram SongJi Won ParkMi Ju KangHong Joo SonJin Tae HongDae Youn Hwang

Published in: PloS one (2019)

The results of the present study provide strong novel evidence that the neuropathological constipation detected in Tg2576 mice is linked to dysregulation of the mAChR signaling pathways and ER stress response.

Keyphrases

signaling pathway
high fat diet induced
pi k akt
irritable bowel syndrome
estrogen receptor
endoplasmic reticulum
epithelial mesenchymal transition
breast cancer cells
induced apoptosis
cognitive decline
type diabetes
wild type
metabolic syndrome
mild cognitive impairment