YES-associated protein-regulated Smad7 worsen epithelial barrier injury of chronic sinusitis with nasal polyps.

Xiaocong JiangLonglan Shu Yijun Liu Yang Shen Xia Ke Jie Liu Yucheng Yang

Published in: Immunity, inflammation and disease (2023)

Higher level of YAP may lead to CRSwNP epithelial barrier injury via the TGF-β1 signaling pathway, and the inhibition of YAP can partially reverse epithelial barrier function.

Keyphrases

signaling pathway
transforming growth factor
epithelial mesenchymal transition
chronic rhinosinusitis
transcription factor
oxidative stress
cell proliferation