Accelerated Cortical Thinning in Schizophrenia Is Associated With Rare and Common Predisposing Variation to Schizophrenia and Neurodevelopmental Disorders.
Javier González-PeñasClara AllozaRachel BrouwerCovadonga M Díaz-CanejaJavier CostasNoemí González-LoisAna Guil GallegoLucía de HoyosXaquín GurriaránÁlvaro Andreu-BernabeuRafael Romero-GarcíaLourdes FañanásJulio BobesAna González-PintoBenedicto Crespo-FacorroLourdes MartorellManuel ArrojoElisabet VilellaAlfonso Gutiérrez-ZotesMarta Perez-RandoMaría Dolores Moltónull nullElizabeth BuimerNeeltje van HarenWiepke CahnMichael O'DonovanRené S KahnCelso ArangoHilleke Hulshoff PolJoost JanssenHugo SchnackPublished in: Biological psychiatry (2024)
Our findings suggest that accelerated cortical thinning, rather than cortical thickness alone, serves as an informative phenotype for neurodevelopmental disruptions in schizophrenia. We highlight the genetic and transcriptomic correlates of this accelerated cortical thinning, emphasizing the need for future longitudinal studies to elucidate the role of genetic variation and the temporal-spatial dynamics of gene expression in brain development and aging in schizophrenia.