Post-Translational Modifications of the DUX4 Protein Impact Toxic Function in FSHD Cell Models.

Renatta N KnoxJocelyn O EidahlLindsay M WallaceSarah G ChouduryAfrooz RashnonejadKatelyn DamanMatthew J GuggenbillerNizar Y SaadMichael E HooverLiwen ZhangOwen E BransonCharles P EmersonMichael A FreitasScott Q Harper

Published in: Annals of neurology (2023)

These results support that DUX4 is regulated by PTMs and set a foundation for developing FSHD drug screens based mechanistically on DUX4 PTMs and modifying enzymes. ANN NEUROL 2023.

Keyphrases

single cell
high throughput
cell therapy
genome wide
protein protein
bone marrow
gene expression
neural network
drug induced