Immune Modulation Effects of Lactobacillus casei Variety rhamnosus on Enterocytes and Intestinal Stem Cells in a 5-FU-Induced Mucositis Mouse Model.

Chun-Yan YeungJen-Shiu Chiang ChiauMei-Lien ChengWai-Tao ChanSzu-Wen ChangChuen-Bin JiangHung-Chang Lee

Published in: Gastroenterology research and practice (2021)

Our results showed that 5-FU caused intestinal inflammation mainly via Th1 and Th17 responses. 5-FU could stimulate stem cells and proliferation cells in a mouse model. We demonstrate chemotherapy could decrease immune competence. Probiotics were shown to modulate the immune response. This is the first study to analyze the immune modulation effects and safety of Lactobacillus strain on enterocytes and intestinal stem cells in a mouse model.

Keyphrases

stem cells
mouse model
immune response
induced apoptosis
cell therapy
oxidative stress
signaling pathway
radiation induced
high glucose
cell cycle arrest
dendritic cells
endoplasmic reticulum stress
drug induced
pi k akt
cell death
endothelial cells
rectal cancer