Suppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway by Ganoderma lucidum: Theoretical and Experimental Study.

Hanan M HassanLamya H Al-WahaibiMohammed A ElmorsyYasmen F Mahran

Published in: Drug design, development and therapy (2020)

GLM attenuated hepatic injury through downregulation of HMGB-1/NF-kB and caspase-3 resulted in modulation of the induced oxidative stress and the subsequent cross-talk between the inflammatory and apoptotic cascade indicating its promising role in DILI.

Keyphrases

cell death
signaling pathway
oxidative stress
transcription factor
hydrogen peroxide
cell proliferation
drug induced
lps induced
pi k akt
anti inflammatory
binding protein