Sichen Formula Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Blocking the TLR4 Signaling Pathways.

Li-Shan YanShuang CuiBrian Chi-Yan ChengXing-Bin YinYi-Wei WangXin-Yu QiuCi-Ren NimaYi ZhangShuo-Feng Zhang

Published in: Drug design, development and therapy (2023)

SC treatment inhibited the inflammatory responses in LPS-induced ALI mouse model/RAW264.7 macrophages. The underlying mechanism of this action may be closely associated with the suppression of TLR4 signaling pathways. These research findings provide further pharmacological justifications for the medicinal use of SC in the management of respiratory diseases.

Keyphrases

inflammatory response
lipopolysaccharide induced
lps induced
mouse model
signaling pathway
toll like receptor
pi k akt
epithelial mesenchymal transition
preterm infants
respiratory tract