Retinoic acid inhibits the angiogenesis of human embryonic stem cell-derived endothelial cells by activating FBP1-mediated gluconeogenesis.

Zhuangzhuang YangMiao YuXuechun LiYuanyuan TuChunyan WangWei LeiMin SongYong WangYing HuangFengyue DingKaili HaoXinglong HanXuan NiLina QuZhenya ShenShijun Hu

Published in: Stem cell research & therapy (2022)

The inhibitory role of RA in glycometabolism and angiogenesis is RAR/FBP1 dependent, and FBP1 may be a novel therapeutic target for pathological angiogenesis.

Keyphrases

endothelial cells
stem cells
high glucose
vascular endothelial growth factor
signaling pathway
bone marrow
cell therapy
wound healing
systemic sclerosis
induced pluripotent stem cells