Statistical mixture design investigation for extraction and quantitation of aporphine alkaloids from the leaves of Unonopsis duckei R.E. Fr. by HPLC-MS/MS.
Pablo R N RochaFlávio A de FreitasCélio F F AngoliniLucas-Smith F VasconcelosAlaíde L B da SilvaEmmanoel Vilaça CostaFelipe Moura Araújo da SilvaMarcos N EberlinGiovana A BataglionPatrícia K SoaresHector Henrique Ferreira KoolenPublished in: Phytochemical analysis : PCA (2018)
The integration of simplex centroid model and quantification by HPLC-MS/MS is promising. Statistical optimisation of the alkaloid extraction and application of selective, sensitive and robust HPLC-MS/MS method will contribute to quality control applications in phytotherapeutic medicines.