Maternal vitamin D supplementation and treadmill exercise attenuated vitamin D deficiency-induced anxiety-and depressive-like behaviors in adult male offspring rats.
Faezeh KazemiShirin BabriParisa KeyhanmehrMahsa Farid-HabibiSepehr Nayebi RadFereshteh FarajdokhtPublished in: Nutritional neuroscience (2022)
It seems that developmental vitamin D deficiency disrupts brain development and has a long-lasting effect on VDR and BDNF signaling in the rat brain resulting in neuropsychiatric disorders in offspring. Therefore, vitamin D supplementation and physical exercise are reasonable strategies to prevent these neurobehavioral impairments.
Keyphrases
- functional connectivity
- resting state
- high fat diet
- stress induced
- high glucose
- diabetic rats
- high intensity
- physical activity
- birth weight
- bipolar disorder
- sleep quality
- drug induced
- pregnancy outcomes
- endothelial cells
- adipose tissue
- insulin resistance
- white matter
- skeletal muscle
- oxidative stress
- pregnant women
- brain injury
- cerebral ischemia
- weight gain
- preterm birth
- gestational age