HMGB2 is a potential diagnostic marker and therapeutic target for liver fibrosis and cirrhosis.

Yi HuangSuthat LiangpunsakulSwetha RudraiahJing MaSantosh K KeshipeddyDennis WrightAntonio CostaDiane BurgessYuxia ZhangNazmul HudaLi WangZhihong Yang

Published in: Hepatology communications (2023)

We conclude that HMGB2 is indispensable for stellate cell activation. Therefore, HMGB2 may serve as a potential therapeutic target to prevent HSC activation during chronic liver injury. The blood HMGB2 level may also serve as a potential diagnostic marker to detect early stage of liver fibrosis and cirrhosis in humans.

Keyphrases

liver fibrosis
liver injury
drug induced
early stage
human health
single cell
squamous cell carcinoma
radiation therapy
cell therapy
risk assessment
lymph node