Metabolomic differences in connective tissue disease-associated versus idiopathic pulmonary arterial hypertension in the PVDOMICS cohort.

Catherine E SimpsonAnna R HemnesMegan GriffithsGabriele GrunigW H Wilson TangJoe G N GarciaJohn BarnardSuzy A ComhairRachel L DamicoStephen C MathaiPaul M Hassounnull null

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

CTD-PAH is characterized by aberrant lipid metabolism that may signal shifted metabolic substrate utilization. Abnormalities in RV-pulmonary vascular FA metabolism may imply reduced capacity for mitochondrial beta oxidation within the diseased pulmonary circulation.

Keyphrases

pulmonary arterial hypertension
pulmonary hypertension
pulmonary artery
mycobacterium tuberculosis
oxidative stress