Linkage disequilibrium and haplotype analysis of Src and Yes1 genes in thyroid cancer.
Asif NisarIshrat MahjabeenAzhar MehmoodMalik Waqar AhmedKhalida KhurshidMahmood Akhtar KayaniPublished in: Future oncology (London, England) (2020)
Purpose: This study was planned to examine the effects of Src and Yes1 single nucleotide polymorphism (SNPs) on the risk of thyroid cancer in 499 patients and 500 controls. Materials & methods: Three SNPs of Src gene and three SNPs of Yes1 gene were analyzed using Tetra-primer ARMS-PCR followed by sequencing. Results: rs121913314 of Src gene genotype TT showed 32-fold increased risk of thyroid cancer and rs2305994 of Yes1 genotypes TT and CT showed 2.7-fold and 16-fold increased risk in thyroid cancer (p < 0.0001). Haplotype analysis revealed that CATGCC, CATGCT, CATGTC, CATGTT, TATGCC and TATGTTA haplotypes are associated with thyroid cancer risk. Conclusion: Results showed that genotypes and allele distribution of Src and Yes1 genes are significantly linked with increased risk of thyroid cancer.
Keyphrases
- genome wide
- tyrosine kinase
- dna methylation
- genome wide identification
- copy number
- end stage renal disease
- newly diagnosed
- single cell
- ejection fraction
- computed tomography
- chronic kidney disease
- peritoneal dialysis
- magnetic resonance imaging
- transcription factor
- gene expression
- patient reported outcomes
- hiv infected
- pet ct
- contrast enhanced
- dual energy
- genome wide association
- human immunodeficiency virus