Dynamic combinatorial libraries of a dimercapto-pillar[5]arene.

Jinwen LuoYunlong GuoPing LiAndrew C-H Sue Chuyang Cheng

Published in: Chemical communications (Cambridge, England) (2022)

We report the synthesis and dynamic covalent chemistry (DCvC) of an A1/A2-dimercapto-functionalized pillar[5]arene (Di-SH-P5). The introduction of thiol moieties into this macrocyclic host makes it an effective building block for making a dynamic combinatorial library (DCL), giving rise to a set of cyclic trimers with intriguing host-guest properties as the dominant constituents.

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