Randomized Phase III BMT CTN Trial of Calcineurin Inhibitor-Free Chronic Graft-Versus-Host Disease Interventions in Myeloablative Hematopoietic Cell Transplantation for Hematologic Malignancies.
Leo LuznikMarcelo C PasquiniBrent R LoganRobert J SoifferJuan WuSteven M DevineNancy L GellerSergio A GiraltHelen E HeslopMary M HorowitzRichard J JonesMark R LitzowAdam MendizabalLori S MufflyEneida R NemecekLynn O'DonnellRichard J O'ReillyRaquel PalenciaJohannes ScheteligLeyla ShuneScott R SolomonSumithira VasuVincent T HoMiguel-Ángel PeralesPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
CNI-free interventions as performed herein did not result in superior CRFS compared with tacrolimus and methotrexate with BM. Lower rates of moderate and severe cGVHD did not translate into improved survival.