Effects of risk factors on evoked pain patterns in rat models of experimental knee osteoarthritis.

Holly T PhilpottGarth BlacklerJ Daniel KlapakKyle K PitchersMadison TomlinsonNiall SmithJaclyn ViehwegerJoseph U UmohDavid W HoldsworthTristan MaerzChristopher Thomas Appleton

Published in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society (2023)

The pattern, intensity, and timing of evoked pain behaviours varied due to OA risk factor exposure and were inconsistently associated with histopathological OA features. These findings may help to explain the challenges with translating pre-clinical OA pain research to multi-morbid clinical OA contexts. This article is protected by copyright. All rights reserved.

Keyphrases

knee osteoarthritis
risk factors
chronic pain
pain management
neuropathic pain
oxidative stress
bariatric surgery
spinal cord injury
obese patients