Clinical Significance and Prognosis Value of Wnt Signaling Pathway in Cervical Cancer.
Afsane BahramiMalihe HasanzadehSoodabeh ShahidSalesZohre YousefiSima KadkhodayanMarjaneh FarazestanianMona Joudi MashhadMasoumeh GharibSeyed Mahdi HassanianSoodabeh ShahidsalesPublished in: Journal of cellular biochemistry (2017)
Cervical cancer is among the most commonly diagnosed cancer in women, supporting the need for identification of novel prognostic and predictive biomarkers to predict the risk of developing of this malignancy or predict the prognosis of patients. Against this background, the activation of the Wingless-type (Wnt)/β-catenin pathway has been suggested as the main dysregulated pathways, which is involved in the multistep process of cervical carcinogenesis, suggesting its value as a potential biomarker or therapeutic target. The aim of current review is to give an overview about the potential application of WNT pathway and its value which is differentially expressed in cervical cancer versus non-tumorigenic tissue as biomarker for risk stratification and predict the prognosis of patients with cervical cancer. J. Cell. Biochem. 118: 3028-3033, 2017. © 2017 Wiley Periodicals, Inc.
Keyphrases
- cell proliferation
- stem cells
- signaling pathway
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- papillary thyroid
- single cell
- prognostic factors
- pi k akt
- epithelial mesenchymal transition
- cell therapy
- type diabetes
- polycystic ovary syndrome
- adipose tissue
- mesenchymal stem cells
- patient reported outcomes
- metabolic syndrome
- climate change
- bone marrow
- oxidative stress
- lymph node metastasis
- insulin resistance