Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells.

Kai LiuMinying ZhengQi ZhaoKexin ZhangZugui LiFangmei FuHao ZhangJiaxing DuYuwei LiShiwu Zhang

Published in: Journal of experimental & clinical cancer research : CR (2020)

CHK1, CHK2-pCDC25C-Ser216-cyclin B1-CDK1, and Aurora A-PLK1-pCDC25C-Ser198-cyclin B1-CDK1 signaling pathways may participate in the formation of PGCCs and different phosphorylation sites of CDC25C may be associated with the genotype of p53.

Keyphrases

cell cycle
cell proliferation
signaling pathway
protein kinase
dna damage response
pi k akt
epithelial mesenchymal transition
dna damage
rare case
cell death