Single-Atom Nanoenzyme-Based Autoluminescence System for Cancer Cell Imaging and Mitochondrial-Targeted Therapy.
Lu FengYuqi WangZhiru BiZizhen WeiHuairong ZhangShusheng ZhangPublished in: ACS applied bio materials (2023)
The autoluminescence nanoplatform based on a single-atom catalyst has the potential to achieve accurate tumor diagnosis and treatment. Taking advantage of this, glycyrrhetinic acid (GA) and chitosan-modified single Fe-N-C atom catalysts (SAF NPs) loaded with luminol-curcumin (Cur) were fabricated (SAF-LCCG). Once delivered to the tumor, this autoluminescence SAF-LCCG could target the mitochondria to restrain tumor metastasis and promote the production of hydrogen peroxide (H 2 O 2 ). Then, SAF NPs with Fenton-like properties could actively utilize intracellular H 2 O 2 to produce ·OH for chemodynamic therapy. After that, excess ·OH and H 2 O 2 were transmitted to luminol to emit blue-violet chemiluminescence (CL) for cancer cell imaging. Synchronously, light was transferred to Cur to produce reactive oxygen species (ROS) which realized photodynamic therapy. Besides, Cur could be served as a chemotherapeutic drug to enhance intracellular ROS for penetrating therapy. More importantly, the massive accumulation of ROS in cancer cells can promote the CL intensity of luminol, which realized the cyclic ROS amplification. This autoluminescence nanoplatform was developed for accurate cancer cell imaging, effective inhibition of tumor metastasis, and synergistic and penetrated treatment of tumors.
Keyphrases
- reactive oxygen species
- photodynamic therapy
- hydrogen peroxide
- high resolution
- cell death
- cancer therapy
- drug delivery
- molecular dynamics
- fluorescence imaging
- stem cells
- oxidative stress
- nitric oxide
- mesenchymal stem cells
- wastewater treatment
- sensitive detection
- risk assessment
- bone marrow
- human health
- drug induced
- ionic liquid
- high intensity
- carbon dioxide
- nucleic acid
- adverse drug
- smoking cessation
- molecularly imprinted