Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation.
Laura AnsoneVita RoviteMonta BrīvībaLauma JagareLīva PelcmaneDaniella BorisovaAnne ThewsRoland LeimingerJanis KlovinsPublished in: International journal of molecular sciences (2024)
Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), can manifest as long-term symptoms in multiple organ systems, including respiratory, cardiovascular, neurological, and metabolic systems. In patients with severe COVID-19, immune dysregulation is significant, and the relationship between metabolic regulation and immune response is of great interest in determining the pathophysiological mechanisms. We aimed to characterize the metabolomic footprint of recovering severe COVID-19 patients at three consecutive timepoints and compare metabolite levels to controls. Our findings add proof of dysregulated amino acid metabolism in the acute phase and dyslipidemia, glycoprotein level alterations, and energy metabolism disturbances in severe COVID-19 patients 3-4 months post-hospitalization.
Keyphrases
- sars cov
- coronavirus disease
- respiratory syndrome coronavirus
- immune response
- early onset
- drug induced
- amino acid
- liver failure
- magnetic resonance
- high resolution
- mass spectrometry
- toll like receptor
- respiratory failure
- dendritic cells
- hepatitis b virus
- inflammatory response
- physical activity
- brain injury
- solid state
- acute respiratory distress syndrome