Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.
Yun QiuYuming MengYajuan JiaXuemei LangHongmei ZhaoLianshu DingTingting WangHong SunSumin GaoPublished in: Cardiovascular drugs and therapy (2022)
IPostC prevented myocardial IR injury partly through PHLPP1/Akt/Mst1 signaling, and abnormalities in this pathway may be responsible for the loss of IPostC cardioprotection in diabetes.