Thinking out of the cranial box in meningitis.

Staphylococcus aureus is a leading cause of infective endocarditis. Meningitis is a rare initial presenting feature of S. aureus infective endocarditis, especially with the absence of other cardio-vascular signs. Differentiating patients with uncomplicated S. aureus bacteraemia from those with underlying infective endocarditis is often challenging.