Apnea, Intermittent Hypoxemia, and Bradycardia Events Predict Late-Onset Sepsis in Extremely Preterm Infants.

Sherry L Kausch Douglas E LakeJuliann M Di FioreDebra E Weese-MayerNelson ClaureNamasivayam Ambalavanan Zachary Andrew Vesoulis Karen D FairchildPhyllis A DenneryAnna Maria HibbsRichard J MartinPremananda Indic Colm P TraversEduardo BancalariAaron HamvasJames S KempJohn L CarrollJ Randall Moorman Brynne Archer Sullivannull null

Published in: medRxiv : the preprint server for health sciences (2024)

We identified cardiorespiratory signatures of late-onset sepsis. Longer IH events were associated with increased sepsis risk but did not change temporally near diagnosis. Increases in bradycardia, apnea, and periodic breathing preceded the clinical diagnosis of sepsis.

Keyphrases

late onset
septic shock
early onset
acute kidney injury
intensive care unit
preterm infants
obstructive sleep apnea
high intensity
gene expression
genome wide
dna methylation
preterm birth