Canagliflozin Pretreatment Attenuates Myocardial Dysfunction and Improves Postcardiac Arrest Outcomes After Cardiac Arrest and Cardiopulmonary Resuscitation in Mice.
Feng JuGeoffrey W AbbottJiaxue LiQifeng WangTing LiuQuanhua LiuZhaoyang HuPublished in: Cardiovascular drugs and therapy (2023)
Canagliflozin offered a strong cardioprotective effect against cardiac arrest and resuscitation-induced cardiac dysfunction. This canagliflozin-induced cardioprotection is mediated by the STAT-3-dependent cell-survival signaling pathway.