Synthesis and Characterization of Novel BMI1 Inhibitors Targeting Cellular Self-Renewal in Hepatocellular Carcinoma.
Monica BartucciMohamed S HusseinEric HuselidKathleen FlahertyMichele PatriziiSaurabh V LaddhaCindy KuiRachel A BigosJohn A GilleranMervat M S El AnsaryMona A M AwadS David KimballDavid J AugeriHatim E SabaawyPublished in: Targeted oncology (2018)
This study demonstrates the ability to identify agents with the propensity for targeting CSCs in HCC that could be explored as novel treatments in the clinical setting.