A simple strategy to reduce the salivary gland and kidney uptake of PSMA-targeting small molecule radiopharmaceuticals.

Teja Muralidhar KalidindiSang-Gyu LeeKaterina JouGoutam ChakrabortyMyrto SkafidaScott T TagawaNeil H BanderHeiko SchoderLisa BodeiNeeta Pandit-TaskarJason S LewisSteven M LarsonJoseph R OsborneNaga Vara Kishore Pillarsetty

Published in: European journal of nuclear medicine and molecular imaging (2021)

The uptake of [177Lu]-PSMA-617 in the salivary gland and kidney can be substantially reduced without significantly impacting tumor uptake by adding cold PSMA-11.

Keyphrases

pet ct
small molecule
pet imaging
positron emission tomography
cancer therapy
computed tomography
protein protein