Enhanced Inhibitory Effect of DC-CIK Cells on Lung Adenocarcinoma via Anti-Tim-3 Antibody and Antiprogrammed Cell Death-1 Antibody and Possible Mechanism.

Liang ZhouQijiu ChenHui ChenLi WangJianyong Zhang

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

Blocking the Tim-3 and PD-1 signaling pathways of DC-CIK cells with antibodies can enhance the killing ability of DC-CIK cells in A549 cells and significantly suppress the invasion and migration ability of A549 cells. The potential mechanism may be related to reduced apoptosis of DC-CIK cells.

Keyphrases

cell cycle arrest
induced apoptosis
cell death
endoplasmic reticulum stress
signaling pathway
dendritic cells
epithelial mesenchymal transition
climate change