Injectable Intrinsic Photothermal Hydrogel Bioadhesive with On-Demand Removability for Wound Closure and MRSA-Infected Wound Healing.
Xinchang KangPengfei GuanCairong XiaoCan LiuYoujun GuanYeying LinYu TianKunyu RenYanting HuangRumin FuChengyun NingLei FanGuo-Xin TanLei ZhouPublished in: Advanced healthcare materials (2023)
Photothermal hydrogel adhesives have yielded promising results for wound closure and infected wound treatment in recent years. However, photothermal hydrogel bioadhesives with on-demand removability without additional nanomaterials-based photothermal agents have rarely been reported in the literature. In this work, an injectable intrinsic photothermal hydrogel bioadhesive with an on-demand removal trait is developed through dynamic cross-linking of gelatin (Gel), tannic acid (TA) quinone, and borax for closing skin incisions and accelerating methicillin-resistant Staphylococcus aureus (MRSA) infected wound healing. The TA quinone containing polyphenol and quinone groups with multifunctional adhesiveness and intrinsic photothermal performance confer the hydrogel adhesive with near-infrared (NIR) responsive antibacterial activity. The cross-linking of pH-sensitive boronic ester (polyphenol-B) and Schiff base bonds endow the hydrogel with great self-healing capacity and on-demand removability. Moreover, the hydrogel possesses good biocompatibility, injectability, and hemostasis. The in vivo experiment in a rat cutaneous incision model and full-thickness MRSA-infected wound model indicate that the smart hydrogel can close wounds efficiently and treat infected ones, demonstrating its superiority in noninvasive treatment of cutaneous incisions and enhancing infected full-thickness wound healing.
Keyphrases
- wound healing
- methicillin resistant staphylococcus aureus
- drug delivery
- cancer therapy
- photodynamic therapy
- drug release
- staphylococcus aureus
- hyaluronic acid
- tissue engineering
- systematic review
- gene expression
- optical coherence tomography
- combination therapy
- genome wide
- dna methylation
- fluorescent probe
- fluorescence imaging
- transition metal