Monocytes prevent apoptosis of iPSCs and promote differentiation of kidney organoids.

Ekaterina PecksenSergey TkachukCristoph SchröderMarc Vives EnrichAnindita NeogCory P JohnsonNiko LachmannHermann HallerYulia Kiyan

Published in: Stem cell research & therapy (2024)

Our data suggest that co-culturing of iPSCs with human monocytes strongly improves differentiation of kidney organoids. An underlying mechanism of monocytic action implies, but not limited to, an increased autophagy in CHIR-treated iPSCs. Our findings enhance the utility of kidney organoid models.

Keyphrases

induced pluripotent stem cells
endoplasmic reticulum stress
oxidative stress
cell death
endothelial cells
dendritic cells
peripheral blood
electronic health record
big data
cell cycle arrest
immune response