Enhanced Cardiomyocyte NLRP3 Inflammasome-Mediated Pyroptosis Promotes d-Galactose-Induced Cardiac Aging.

Wen-Bin LiuSui-Sui WangXu ZhangZe-Zhi KeXiu-Yun WenJie ZhaoXiao-Dong Zhuang Li-Zhen Liao

Published in: Journal of the American Heart Association (2024)

The reactive oxygen species/nuclear factor κ-light-chain enhancer of activated B cells/NLRP3 signaling pathway loop contributes to d-galactose-treated cardiomyocyte senescence and cardiac aging.

Keyphrases

nlrp inflammasome
nuclear factor
high glucose
reactive oxygen species
signaling pathway
endothelial cells
toll like receptor
left ventricular
transcription factor
angiotensin ii
pi k akt
dna damage
binding protein
heart failure
inflammatory response
immune response
induced apoptosis