Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC.

Martin HasselblattChristian ThomasAniello FedericoSusanne BensMats HellströmOlivera Casar-BorotaUwe KordesJulia E NeumannMatthias DottermuschFausto J RodriguezAndrea C LoSylvia ChengGlenda HendsonJuliette HukinChristian HartmannArend KochDavid CapperReiner SiebertWerner PaulusKarolina NemesPascal D JohannMichael C FrühwaldMarcel Kool

Published in: Neuropathology and applied neurobiology (2022)

Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant, is a histopathological distinct low-grade lesion encountered in older children and young adults that shows epigenetic similarity with ATRT-MYC and has the potential for malignant progression.

Keyphrases

low grade
young adults
high grade
dna methylation
gene expression
transcription factor
wild type
physical activity
middle aged
childhood cancer
human health
climate change