Genetic polymorphism patterns suggest a genetic driven inflammatory response as pathogenesis in appendicitis.
Jan DimbergMarie RubérMarita SkarstedtManne AnderssonRoland Erik AnderssonPublished in: International journal of colorectal disease (2019)
The association of gene variants on risk of appendicitis and its severity suggest an etiologic role of genetically regulated inflammatory response. This may have implications for understanding the prognosis of untreated appendicitis as a possible self-limiting disorder and for understanding the inverse association of appendicitis with ulcerative colitis.