Innate IL-23/Type 17 immune responses mediate the effect of the 17q21 locus on childhood asthma.
Ni WangSusanne BrixJeppe Madura LarsenAnna H ThysenMorten A RasmussenChristopher T WorkmanJakob StokholmKlaus BønnelykkeHans BisgaardBo Lund ChawesPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)
The 17q21 effect on childhood asthma and exacerbations was partly mediated by deregulation of IL-23 in response to intracellular microbial ligands, which may suggest ineffective clearance of intracellular pathogens in the lungs.