Tailored antimicrobial activity and long-term cytocompatibility of plasma polymer silver nanocomposites.
Steffi WiesenmuellerPeter CierniakMartin JuebnerEnrico KoernerDirk HegemannKatja Mercer-Chalmers-BenderPublished in: Journal of biomaterials applications (2019)
The deposition of coatings enabling antibacterial properties in combination with cytocompatibility remains a challenge for biomaterial applications, such as in medical devices. Silver is one of the most utilized antibacterial surface components, due to its efficacy and extensive applicability. In this work, silver-containing plasma polymer nanocomposites (single layer and multilayers) were developed and tested, with a focus on cytotoxicity and bactericidal function, on the NIH3T3 mammalian cell line as well as Gram-negative ( Pseudomonas aeruginosa) and Gram-positive ( Staphylococcus aureus) bacterial strains. The data demonstrate that a tuneable Ag+ release is required, allowing sufficient antimicrobial activity while retaining appropriate cytocompatibility over the entire testing period of up to eight days.
Keyphrases
- gram negative
- silver nanoparticles
- multidrug resistant
- gold nanoparticles
- pseudomonas aeruginosa
- staphylococcus aureus
- reduced graphene oxide
- acinetobacter baumannii
- biofilm formation
- visible light
- escherichia coli
- cystic fibrosis
- drug resistant
- carbon nanotubes
- electronic health record
- anti inflammatory
- machine learning
- methicillin resistant staphylococcus aureus
- essential oil
- artificial intelligence
- data analysis
- wound healing