Disentangling the common genetic architecture and causality of rheumatoid arthritis and systemic lupus erythematosus with COVID-19 outcomes: genome-wide cross trait analysis and bi-directional Mendelian randomization study.

Minhao YaoXin HuangYunshan GuoJie V ZhaoZhonghua Liu

Published in: Journal of medical virology (2023)

Our novel findings improved the understanding of the genetic aetiology shared by COVID-19, RA and SLE, and suggested an increased risk of COVID-19 hospitalization in people with higher genetic liability to RA. This article is protected by copyright. All rights reserved.

Keyphrases

genome wide
disease activity
systemic lupus erythematosus
coronavirus disease
rheumatoid arthritis
sars cov
dna methylation
copy number
ankylosing spondylitis
respiratory syndrome coronavirus
interstitial lung disease
type diabetes
metabolic syndrome
insulin resistance
skeletal muscle
gene expression
drug induced