Pressure-Driven Insulin Release Overcomes Limitations of Diffusion for Encapsulated Islet Cell Therapy.

Ella A ThomsonRayhan A LalHaixia XuSooyeon LeeHannah MoellerJustin P AnnesAda S Y Poon

Published in: bioRxiv : the preprint server for biology (2023)

Diffusion-based insulin delivery from macroencapsulated islet cells is incompatible with physiologic glucose control, a constraint addressed through pressure-based insulin delivery.

Keyphrases

cell therapy
type diabetes
glycemic control
induced apoptosis
stem cells
mesenchymal stem cells
blood glucose
oxidative stress
insulin resistance
bone marrow