Immunohistochemical Detection of Synuclein Pathology in Skin in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinsonism.

Ahmed Al-QassabiTsu-Shuen TsaoAdriana RacoltaThomas KremerMarta CañameroAnton BelousovMadison A SantanaRachel C BeckHongjun ZhangJeffrey MeridewJudith PughFangru LianMark D RobidaMirko RitterChristian CzechThomas G BeachLidija Pestic-DragovichKirsten I TaylorWagner ZagoLei TangSebastian DziadekRonald B Postuma

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

Even with a single 3-mm punch biopsy, there is considerable promise for using pathological alpha-synuclein deposition in skin to diagnose both clinical and prodromal PD. © 2020 International Parkinson and Movement Disorder Society.

Keyphrases

loop mediated isothermal amplification
soft tissue
parkinson disease
wound healing
physical activity
ultrasound guided
sleep quality
big data
real time pcr
fine needle aspiration
sensitive detection