Application of the adverse outcome pathway framework for investigating skin sensitization potential of nanomaterials using new approach methods.
Soraia F BezerraBruna Dos Santos RodriguesArtur C G da SilvaRenato I de ÁvilaHallison R G BritoEmílio R CintraDanillo F M C VelosoEliana M LimaMarize Campos ValadaresPublished in: Contact dermatitis (2020)
Our study suggests the potential immunotoxicity of nanomaterials and highlights the importance of studying the immunotoxicity and skin sensitization potential of nanomaterials to anticipate possible human health risks using standardized mechanistic nonanimal methods with high predictive accuracy. Therefore, it contributes toward the applicability of existing OECD (Organisation for Economic Co-operation and Development) testing guidelines for accurate assessment of nanomaterial skin sensitization potential.