C-reactive protein-induced activated partial thromboplastin time prolongation in heparinized samples is attenuated by elevated factor VIII.

Vadim KostousovSridevi DevarajKaren BruzdoskiLisa HenschShiu-Ki HuiJun Teruya

Published in: International journal of laboratory hematology (2020)

In vitro CRP-induced aPTT prolongation is not observed in pediatric ECMO samples due to concomitant FVIII increase. Discordant changes of CRP and FVIII in plasma could contribute to aPTT/anti-Xa discrepancies observed during heparin therapy in the pediatric population. The anti-Xa assay is preferable for heparin monitoring in pediatric ECMO settings.

Keyphrases

drug induced
extracorporeal membrane oxygenation
high glucose
diabetic rats
acute respiratory distress syndrome
venous thromboembolism
growth factor
high throughput
endothelial cells
oxidative stress
intensive care unit