Thyroglobulin and thyroglobulin antibodies: assay-dependent management consequences in patients with differentiated thyroid carcinoma.
Caroline M J van KinschotRobin P PeetersSjoerd A A van den BergFrederik A VerburgCharlotte van NoordTessa M van GinhovenW Edward VisserPublished in: Clinical chemistry and laboratory medicine (2022)
A substantial portion of DTC patients were classified differently dependent on which Tg and TgAb assays are used, when applying the cut-off values as defined in clinical guidelines. Such differences can significantly affect clinical management. In the context of large between-method variation, the recommended Tg cut-offs in guidelines should be used with wisdom rather than as fixed cut-offs.