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Genetic mapping of novel modifiers for ApcMin induced intestinal polyps' development using the genetic architecture power of the collaborative cross mice.

Alexandra DormanIlona BinenbaumHanifa J Abu-Toamih AtamniAristotelis ChatziioannouIan TomlinsonRichard MottFuad A Iraqi
Published in: BMC genomics (2021)
Genomic structure of the CC lines has allowed us to identify novel modifiers and confirmed some of the previously mapped modifiers. Key genes involved mainly in metabolic and immunological processes were identified. Future steps in this analysis will be to identify regulatory elements - and possible epistatic effects - located in the mapped QTL.
Keyphrases
  • copy number
  • genome wide
  • high density
  • high resolution
  • high glucose
  • transcription factor
  • diabetic rats
  • high fat diet induced
  • current status
  • dna methylation
  • type diabetes
  • insulin resistance