Combining Olaparib and Ascorbic Acid on Nanoparticles to Enhance the Drug Toxic Effects in Pancreatic Cancer.

Francisco Quiñonero Belén Parra-Torrejón Gloria Belén Ramírez-Rodríguez Víctor Garcés José Manuel Delgado-LópezCristina Jiménez-LunaGloria PerazzoliConsolación Melguizo Jose Carlos PradosRaul Ortíz

Published in: International journal of nanomedicine (2023)

Calcium phosphate NPs, a highly biocompatible and biodegradable system, were an ideal vector for the OLA and AA co-treatment in PC, inducing significant therapeutic benefits relative to free OLA, including cytotoxicity, induction of apoptosis, inhibition of cell migration, tumor growth, and survival.

Keyphrases

cell migration
oxidative stress
drug delivery
endoplasmic reticulum stress
cell death
cell cycle arrest
ionic liquid
emergency department
drug release
adverse drug
free survival
drug induced
cell proliferation
replacement therapy
pi k akt