A closed-loop ventilation mode that targets the lowest work and force of breathing reduces the transpulmonary driving pressure in patients with moderate-to-severe ARDS.
Laura A Buiteman-KruizingaDavid M P van MeenenLieuwe D J BosPim L J van der HeidenFrederique PaulusMarcus J SchultzPublished in: Intensive care medicine experimental (2023)
In this small physiological study, when compared to conventional pressure controlled ventilation INTELLiVENT-ASV reduced the transpulmonary ΔP in patients in the early phase of moderate-to-severe ARDS. This closed-loop ventilation mode also led to a lower inspiratory transpulmonary pressure and a lower respiratory rate, thereby reducing the intensity of ventilation. Trial registration Clinicaltrials.gov, NCT03211494, July 7, 2017. https://clinicaltrials.gov/ct2/show/NCT03211494?term=airdrop&draw=2&rank=1 .
Keyphrases
- mechanical ventilation
- respiratory failure
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- high intensity
- end stage renal disease
- intensive care unit
- ejection fraction
- newly diagnosed
- early onset
- computed tomography
- clinical trial
- peritoneal dialysis
- single molecule
- phase iii
- phase ii
- contrast enhanced
- gestational age
- preterm birth
- dual energy
- open label
- pet ct