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Matrix vesicles from dental follicle cells improve alveolar bone regeneration via activation of the PLC/PKC/MAPK pathway.

Genzheng YiSiyuan ZhangYue MaXueting YangFangjun HuoYan ChenBo YangWeidong Tian
Published in: Stem cell research & therapy (2022)
In summary, our findings revealed a novel cell-free regenerative therapy for repairing alveolar bone defects by specific MV subtypes and suggest that PLC/PKC/MAPK pathways contribute to MVs-mediated alveolar bone regeneration.
Keyphrases
  • bone regeneration
  • cell free
  • signaling pathway
  • induced apoptosis
  • oxidative stress
  • pi k akt
  • stem cells
  • cell cycle arrest
  • mesenchymal stem cells
  • single cell
  • endoplasmic reticulum stress
  • cell death
  • oral health